Gastrointestinal manifestations after Roux-en-Y gastric bypass surgery in individuals with and without type 2 diabetes
نویسندگان
چکیده
Background Roux-en-Y gastric bypass (RYGB) surgery is an effective treatment for obesity, which improves cardiovascular health and reduces the risk of premature mortality. However, some reports have suggested that RYGB may predispose patients to adverse outcomes, such as inflammatory bowel disease (IBD) colorectal cancer. Objectives The present prospective study aimed evaluate impact on factors gastrointestinal inflammation in individuals with without type 2 diabetes (T2D). Setting University hospital setting Finland. Methods Blood fecal samples were collected at baseline 6 months after from 30 individuals, 16 had T2D 14 nondiabetics. There also single visits healthy reference patients. Changes factors, serum cholesterol, triglycerides investigated before surgery. Fecal analyzed calprotectin, anti-Saccharomyces cerevisiae immunoglobulin A antibodies (ASCA), active lipopolysaccharide (LPS) concentration, short-chain fatty acids (SCFAs), intestinal alkaline phosphatase activity, methylglyoxal-hydro-imidazolone (MG-H1) protein adducts formation. Results After RYGB, weight decreased average ?21.6% (?27.2 ± 7.8 kg), excess loss averaged 51%, there improvements factors. calprotectin levels (P < .001), LPS concentration .002), ASCA .02), MG-H1 .02) values increased significantly, whereas SCFAs, especially acetate .002) butyrate .03) levels, significantly lowered. Conclusion homeostasis altered several markers suggesting inflammation; however, clinical significance detected changes currently uncertain. As chronic effects, our findings relevance association between risks incident IBD
منابع مشابه
Alterations in gastrointestinal physiology after Roux-en-Y gastric bypass.
m h a r orbid obesity is increasing exponentially in the US. pproximately 33.3% of Americans were obese in 1991, ersus 25.4% in 1976. Currently, 54.5% of Americans re overweight, with a body mass index 25. Diet and xercise are implemented initially, they usually fail after years. In response to this epidemic, surgical therapies or morbid obesity have evolved. There are several diferent weight l...
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ژورنال
عنوان ژورنال: Surgery for Obesity and Related Diseases
سال: 2021
ISSN: ['1878-7533', '1550-7289']
DOI: https://doi.org/10.1016/j.soard.2020.10.021